HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetate → 5-hydroxy-8-{1-hydroxy-2-[1-(4-methoxy-benzyl)-cyclopropylamino]-ethyl}-4H-benzo[1,4]oxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | 1-(4-Methoxybenzyl)cyclopropanamine | HCID 23106092 | — |
| Reactant | 5-(benzyloxy)-8-(dihydroxyacetyl)-2H-1,4-benzoxazin-3(4H)-one | HCID 23106148 | — |
| Product | 5-hydroxy-8-{1-hydroxy-2-[1-(4-methoxy-benzyl)-cyclopropylamino]-ethyl}-4H-benzo[1,4]oxazin-3-one | HCID 11689523 | — |
Reaction Steps
Reaction of 329 mg (1 mmol) 5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 177 mg (1 mmol) 1-(4-methoxy-benzyl)-cyclopropylamine according to general method 3. Yield: 39 mg (8%, trifluoroacetate); mass spectroscopy: [M+H]+=385.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423035B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-7e2a402128f04bb184dac64ae54acecb |
| Source note | uspto-grants-2008_09 |