2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyrimidin-2-ylamine

HRID 298311Notes

Reaction equation

HRID 298311 reaction equation
[Br:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH3:20])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:12]2)[cH:6]1.[NH2:21][c:22]1[n:23][cH:24][c:25]([B:28]2[O:29][C:30]([CH3:31])([CH3:32])[C:33]([CH3:34])([CH3:35])[O:36]2)[cH:26][n:27]1>>[c:2]1(-[c:25]2[cH:24][n:23][c:22]([NH2:21])[n:27][cH:26]2)[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH3:20])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:12]2)[cH:6]1

Participants

3

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol esterHCID 574687362-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-methyl-pyrimidine

Product 1

HCID 602093635-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyrimidin-2-ylamine

Sources & evidence

ORD record
ord-de69a3a8eccd4b71aae16972f4445c23
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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