Trifluoroacetate → 5-hydroxy-8-(1-hydroxy-2-{1-[2-(4-methoxy-phenyl)-ethyl]-cyclopropylamino}-ethyl)-4H-benzo[1,4]oxazin-3-one

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetate	HCID 84468	—
Reactant	5-(benzyloxy)-8-(dihydroxyacetyl)-2H-1,4-benzoxazin-3(4H)-one	HCID 23106148	—
Reactant	1-[2-(4-Methoxyphenyl)ethyl]cyclopropan-1-amine	HCID 59789244	—
Product	5-hydroxy-8-(1-hydroxy-2-{1-[2-(4-methoxy-phenyl)-ethyl]-cyclopropylamino}-ethyl)-4H-benzo[1,4]oxazin-3-one	HCID 23106085	—

Reaction Steps

Prepared according to general method 3 from 329 mg (1 mmol) 5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 191 mg (1 mmol) 1-[2-(4-methoxy-phenyl)-ethyl]-cyclopropylamine. Yield: 55 mg (11%, trifluoroacetate); mass spectroscopy: [M+H]+=399.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07423035B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-37a55f94b98b442f9c8dd7294d328d6a
Source note	uspto-grants-2008_09