Trifluoroacetate → HCID 59789230, compound

HRID 29842Notes

Reaction equation

C([O:8][C:9]1[C:14]2[NH:15][C:16](=[O:19])[CH2:17][O:18][C:13]=2[C:12]([C:20](=[O:24])[CH:21](O)O)=[CH:11][CH:10]=1)C1C=CC=CC=1.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:35]=[CH:36][C:37]=1[O:38][CH3:39])[CH2:30][C:31]1([NH2:34])[CH2:33][CH2:32]1.FC(F)(F)C([O-])=O>>[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:35]=[CH:36][C:37]=1[O:38][CH3:39])[CH2:30][C:31]1([NH:34][CH2:21][CH:20]([C:12]2[C:13]3[O:18][CH2:17][C:16](=[O:19])[NH:15][C:14]=3[C:9]([OH:8])=[CH:10][CH:11]=2)[OH:24])[CH2:32][CH2:33]1

Participants

Reactant 3

HCID 84468Trifluoroacetate

HCID 231061101-(3,4-Dimethoxy-benzyl)-cyclopropylamine

HCID 231061485-(benzyloxy)-8-(dihydroxyacetyl)-2H-1,4-benzoxazin-3(4H)-one

Product 1

HCID 59789230HCID 59789230, compound

Procedure

Prepared according to general method 3 from 329 mg (1 mmol) 5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 207 mg (1 mmol) 1-(3,4-dimethoxy-benzyl)-cyclopropylamine. Yield: 15 mg (3%, trifluoroacetate); mass spectroscopy: [M+H]+=415.

Workup

customPrepared

Sources & evidence

ORD record: ord-0caf997360b44720a9f8ebe5c8b8f15a
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07423035B2

Reaction notes

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