Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Phenylcyclopropanemethanamine → 5-hydroxy-8-{1-hydroxy-2-[(1-phenyl-cyclopropylmethyl)-amino]-ethyl}-4H-benzo[1,4]oxazin-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Phenylcyclopropanemethanamine | HCID 70287 | — |
| 반응물 | 5-(benzyloxy)-8-(dihydroxyacetyl)-2H-1,4-benzoxazin-3(4H)-one | HCID 23106148 | — |
| 생성물 | 5-hydroxy-8-{1-hydroxy-2-[(1-phenyl-cyclopropylmethyl)-amino]-ethyl}-4H-benzo[1,4]oxazin-3-one | HCID 11508653 | — |
반응 단계
Prepared from 329 mg (1 mmol) 5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 147 mg (1 mmol) C-(1-phenyl-cyclopropyl)-methylamine. Final purification by chromatography (silica gel; dichloromethane/methanol gradient). Yield: 30 mg (8%); mass spectroscopy: [M+H]+=355.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423035B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-d5d372f59c294a2093a33b43d5fb4233 |
| 출처 메모 | uspto-grants-2008_09 |