反应详情

258 mg (0.51 mmol) 8-benzyloxy-5-{1-hydroxy-2-[1-(4-methoxy-benzyl)-cyclopropylamino]-ethyl}-1H-quinolin-2-one in 10 mL methanol are hydrogenated with palladium on charcoal as catalyst at 3 bar. Then the catalyst is separated off, the solvent is distilled off and the residue is purified by chromatography (reverse phase, water/acetonitrile gradient). Yield: 12 mg (6%); mass spectroscopy: [M+H]+=381.

1. customThen the catalyst is separated off
2. distillationthe solvent is distilled off
3. customthe residue is purified by chromatography (reverse phase, water/acetonitrile gradient)