HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one → 8-benzyloxy-5-{1-hydroxy-2-[1-(4-trifluoromethyl-benzyl)-cyclopropylamino]-ethyl}-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one | HCID 13897641 | — |
| Reactant | 1-(4-Trifluoromethylbenzyl)cyclopropylamine | HCID 23106138 | — |
| Product | 8-benzyloxy-5-{1-hydroxy-2-[1-(4-trifluoromethyl-benzyl)-cyclopropylamino]-ethyl}-1H-quinolin-2-one | HCID 23106117 | — |
Reaction Steps
Reaction of 587 mg (2.0 mmol) 8-benzyloxy-5-oxiranyl-1H-quinolin-2-one and 710 mg (3.3 mmol) 1-(4-trifluoromethyl-benzyl)-cyclopropylamine is carried out analogously to Example 40a43a). Yield: 322 mg (32%); mass spectroscopy: [M+H]+=509.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423035B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-6a791ced7cc34b16870569d8ce5c27e4 |
| Source note | uspto-grants-2008_09 |