Ethanol → Pioglitazone

HRID 298925Notes

Reaction equation

HRID 298925 reaction equation
[CH3:39][CH2:40][OH:41].[K+:17].[O:18]([S:19]([c:20]1[cH:21][cH:22][c:23]([CH3:24])[cH:25][cH:26]1)(=[O:27])=[O:28])[CH2:29][CH2:30][c:31]1[n:32][cH:33][c:34]([CH2:37][CH3:38])[cH:35][cH:36]1.[OH-:16].[OH:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][CH:7]2[C:8](=[O:13])[NH:9][C:10](=[O:12])[S:11]2)[cH:14][cH:15]1>>[O:1]([c:2]1[cH:3][cH:4][c:5]([CH2:6][CH:7]2[C:8](=[O:13])[NH:9][C:10](=[O:12])[S:11]2)[cH:14][cH:15]1)[CH2:29][CH2:30][c:31]1[n:32][cH:33][c:34]([CH2:37][CH3:38])[cH:35][cH:36]1

Participants

6

Reactant 5

HCID 702EthanolHCID 813Potassium CationHCID 961HydroxideHCID 101983975-(4-Hydroxybenzyl)thiazolidine-2,4-dioneHCID 112667342-(5-Ethyl-2-pyridyl)ethyl Tosylate

Product 1

HCID 4829Pioglitazone

Sources & evidence

ORD record
ord-414eedd882c74f8f970f42e4adb88bbb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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