4-Fluorobenzyl bromide → HCID 69200466, compound

HRID 29904Notes

Reaction equation

HRID 29904 reaction equation
[CH2:1]([N:8]1[CH2:26][CH2:25][C:11]2[N:12]=[C:13]([C:17]3[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([Cl:24])[CH:18]=3)[N:14]=[C:15]([OH:16])[C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:27][C:28]1[CH:35]=[CH:34][C:31]([CH2:32]Br)=[CH:30][CH:29]=1>>[CH2:1]([N:8]1[CH2:26][CH2:25][C:11]2[N:12]=[C:13]([C:17]3[CH:18]=[C:19]([Cl:24])[CH:20]=[C:21]([Cl:23])[CH:22]=3)[N:14]=[C:15]([O:16][CH2:32][C:31]3[CH:34]=[CH:35][C:28]([F:27])=[CH:29][CH:30]=3)[C:10]=2[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 178517513HCID 178517513, compound2×

Product 1

HCID 69200466HCID 69200466, compound

Procedure

The title compound was prepared from 6-benzyl-2-(3,5-dichloro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ol (which was obtained in Intermediate 7) and 4-fluorobenzyl bromide according to Method A; 1H NMR (DMSO-d6, 300 MHz) δ 3.67 (br s, 4H), 4.24 (br s, 2H), 4.43 (br s, 2H), 5.64 (s, 2H), 7.25 (t, J=8.9 Hz, 2H), 7.60 (m, 3H), 7.83 (s, 1H), 7.95 (s, 1H); LC retention time 3.21 min; MS: m/z (ESI) 494 (M+H).

Sources & evidence

ORD record
ord-c4c0dc9b34c249d4baa6e687706fb634
Source dataset
uspto-grants-2008_09
Patent number
US07423044B2

Reaction notes

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