Methanol → tert-butyl N-(azetidin-3-ylmethyl)carbamate

HRID 299110Notes

Reaction equation

HRID 299110 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH:10]1[CH2:11][N:12]([CH:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[CH2:13]1.[CH3:27][OH:28].[OH-:29].[OH-:30].[Pd+2:31]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH:10]1[CH2:11][NH:12][CH2:13]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 22257620tert-Butyl ((1-benzhydrylazetidin-3-yl)methyl)carbamate

Product 1

HCID 15346872tert-butyl N-(azetidin-3-ylmethyl)carbamate

Sources & evidence

ORD record
ord-c162471dc3824be08f8d088547e5a981
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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