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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29913Generated: October 28, 2026

1-(Bromomethyl)-4-(trifluoromethyl)benzene → 6-Benzyl-2-(3-nitrophenyl)-4-{[4-(trifluoromethyl)benzyl]oxy}-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

https://huagongshe.com/reaction/29913

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 123062—
ReactantHCID 178526607HCID 178526607—
Product6-Benzyl-2-(3-nitrophenyl)-4-{[4-(trifluoromethyl)benzyl]oxy}-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineHCID 69200997—

Reaction Steps

The title compound was prepared from 6-benzyl-2-(3-nitro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ol (which was obtained in Intermediate 9) and 4-(trifluoromethyl)benzyl bromide according to Method A; LC retention time 2.95 min; MS: m/z (ESI) 521 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423044B2
Source datasetuspto-grants-2008_09
ORD IDord-882a678aeeea4e0fbe6275bfa2bfd57e
Source noteuspto-grants-2008_09