1-Chloro-7-methoxy-4-(4-methoxyphenyl)phthalazine → 7-Methoxy-4-(4-methoxyphenyl)-N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]phthalazin-1-amine

HRID 29929Notes

Reaction equation

HRID 29929 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][N:12]1[CH:17]2[CH2:18][CH2:19][CH:13]1[CH2:14][CH:15]([NH2:20])[CH2:16]2.Cl[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=2)[C:25]([C:34]2[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=2)=[N:24][N:23]=1>>[CH3:33][O:32][C:29]1[CH:30]=[C:31]2[C:26]([C:25]([C:34]3[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=3)=[N:24][N:23]=[C:22]2[NH:20][CH:15]2[CH2:16][CH:17]3[N:12]([CH2:11][C:2]4[CH:3]=[CH:4][C:5]5[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=5)[CH:1]=4)[CH:13]([CH2:19][CH2:18]3)[CH2:14]2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 576917601-Chloro-7-methoxy-4-(4-methoxyphenyl)phthalazineHCID 61233091N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]amine

Product 1

HCID 692094717-Methoxy-4-(4-methoxyphenyl)-N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]phthalazin-1-amine

Procedure

This compound is obtained according to the procedure described in 1.4. by reacting N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]amine and 1-chloro-7-methoxy-4-(4-methoxyphenyl)phthalazine.

Workup

  1. customThis compound is obtained

Sources & evidence

ORD record
ord-9a9513cde0af418983bad3b51b0595cd
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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