4-Amino-1-(2-naphthyl)methylpiperidine → 7-methoxy-4-(4-methoxyphenyl)-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]phthalazin-1-amine

HRID 29940Notes

Reaction equation

HRID 29940 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[N:4][N:3]=1.[NH2:22][CH:23]1[CH2:28][CH2:27][N:26]([CH2:29][C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:31]=2)[CH2:25][CH2:24]1>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6]([C:5]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)=[N:4][N:3]=[C:2]2[NH:22][CH:23]2[CH2:24][CH2:25][N:26]([CH2:29][C:30]3[CH:39]=[CH:38][C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH:31]=3)[CH2:27][CH2:28]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 111958234-Amino-1-(2-naphthyl)methylpiperidineHCID 576917601-Chloro-7-methoxy-4-(4-methoxyphenyl)phthalazine

Product 1

HCID 576916847-methoxy-4-(4-methoxyphenyl)-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]phthalazin-1-amine

Procedure

This compound is obtained according to the procedure described in 1.4. by reacting 1-chloro-7-methoxy-4-(4-methoxyphenyl)phthalazine described in 3.4 with 4-amino-1-(naphthalen-2-ylmethyl)piperidine.

Workup

  1. customThis compound is obtained

Sources & evidence

ORD record
ord-2aeeec072e9245ecbbdcc2b1b27f0308
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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