Acetone → 4-[4-(4-Methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 299651Notes

Reaction equation

HRID 299651 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[s:15][cH:16][c:17]([CH2:19][Cl:20])[n:18]2)[CH2:12][CH2:13]1.[CH3:21][S:22](=[O:23])(=[O:24])[c:25]1[cH:26][cH:27][c:28]([OH:31])[cH:29][cH:30]1.[CH3:38][C:39](=[O:40])[CH3:41].[K+:32].[K+:33].[O-:34][C:35]([O-:36])=[O:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[s:15][cH:16][c:17]([CH2:19][O:31][c:28]3[cH:27][cH:26][c:25]([S:22]([CH3:21])(=[O:23])=[O:24])[cH:30][cH:29]3)[n:18]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 1233504-(Methylsulfonyl)phenolHCID 57423790Tert-butyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

Product 1

HCID 250241364-[4-(4-Methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-c68fd907db69499791ff3094991b6b98
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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