Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29990Generated: October 25, 2026

2-Bromo-5-methoxybenzoic acid → 5-Methoxy-2-(4-trifluoromethylbenzoyl)benzoic acid

https://huagongshe.com/reaction/29990

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-5-methoxybenzoic acidHCID 89906—
ReactantN-Methoxy-N-methyl-4-(trifluoromethyl)benzamideHCID 14069348—
ReactantButyllithiumHCID 178418339—
Product5-Methoxy-2-(4-trifluoromethylbenzoyl)benzoic acidHCID 69209321—

Reaction Steps

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with N-methoxy-N-methyl-4-trifluoromethylbenzamide. It is used in crude form in the following reaction.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423030B2
Source datasetuspto-grants-2008_09
ORD IDord-45701e78000e4b479be07ec207dbd8b3
Source noteuspto-grants-2008_09