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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29996Generated: October 25, 2026

2-Bromo-5-methoxybenzoic acid → 5-Methoxy-2-(4-methylbenzoyl)benzoic acid

https://huagongshe.com/reaction/29996

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-5-methoxybenzoic acidHCID 89906—
ReactantN-Methoxy-N,4-dimethylbenzamideHCID 5133773—
ReactantButyllithiumHCID 178418339—
Product5-Methoxy-2-(4-methylbenzoyl)benzoic acidHCID 69211636—

Reaction Steps

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with N-methoxy-N-methyl-4-methylbenzamide. It is used in crude form in the following reaction.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423030B2
Source datasetuspto-grants-2008_09
ORD IDord-b1437b4d90304f05885ff4e590690d41
Source noteuspto-grants-2008_09