2-Bromo-5-methoxybenzoic acid → 5-Methoxy-2-pentanoylbenzoic acid

HRID 30000Notes

Reaction equation

HRID 30000 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.[CH2:18]([C:22](N(OC)C)=[O:23])[CH2:19][CH2:20][CH3:21]>>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:2]([C:22](=[O:23])[CH2:18][CH2:19][CH2:20][CH3:21])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 899062-Bromo-5-methoxybenzoic acidHCID 3801384N-methoxy-N-methylpentanamideHCID 178418339Butyllithium

Product 1

HCID 692141535-Methoxy-2-pentanoylbenzoic acid

Procedure

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with butyl-N-methoxy-N-methylcarboxamide. It is used in crude form in the following reaction.

Workup

  1. customThis compound is synthesized
  2. customin the following reaction

Sources & evidence

ORD record
ord-36942ab93f9d4d2a84ed0f1e7103b19e
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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