2-Bromo-5-methoxybenzoic acid → HCID 69213878, compound

HRID 30026Notes

Reaction equation

HRID 30026 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:29]=[C:30]([O:32][CH3:33])[CH:31]=1)[C:23](N(OC)C)=[O:24]>>[CH3:33][O:32][C:30]1[CH:29]=[C:22]([CH:21]=[C:20]([O:19][CH3:18])[CH:31]=1)[C:23]([C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])=[O:24]

Participants

4

Reactant 3

HCID 899062-Bromo-5-methoxybenzoic acidHCID 11117713N,3,5-Trimethoxy-N-methylbenzamideHCID 178418339Butyllithium

Product 1

HCID 69213878HCID 69213878, compound

Procedure

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with 3,5-dimethoxy-N-methoxy-N-methylbenzamide. It is crystallized from diisopropyl ether.

Workup

  1. customThis compound is synthesized
  2. customIt is crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-3966952913bd46f699089d54e84f0e7f
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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