2-Bromo-5-methoxybenzoic acid → 5-Methoxy-2-(2-phenylpropionyl)benzoic acid

HRID 30029Notes

Reaction equation

HRID 30029 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.CON(C)[C:21](=[O:30])[CH:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH3:23]>>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:2]([C:21](=[O:30])[CH:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH3:23])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 899062-Bromo-5-methoxybenzoic acidHCID 10845458N-methoxy-N-methyl-2-phenylpropanamideHCID 178418339Butyllithium

Product 1

HCID 692152495-Methoxy-2-(2-phenylpropionyl)benzoic acid

Procedure

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with N-methoxy-N-methyl-2-phenylpropionamide. It is used in crude form in the following reaction.

Workup

  1. customThis compound is synthesized
  2. customin the following reaction

Sources & evidence

ORD record
ord-2ff23645c6d142b2b468d9b17dfe0cb2
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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