2-Bromo-5-methoxybenzoic acid → 2-(4-Bromobenzoyl)-5-methoxybenzoic acid

HRID 30051Notes

Reaction equation

HRID 30051 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.[Br:18][C:19]1[CH:30]=[CH:29][C:22]([C:23](N(OC)C)=[O:24])=[CH:21][CH:20]=1>>[Br:18][C:19]1[CH:30]=[CH:29][C:22]([C:23]([C:2]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[O:24])=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 899062-Bromo-5-methoxybenzoic acidHCID 109992524-Bromo-N-methoxy-N-methylbenzamideHCID 178418339Butyllithium

Product 1

HCID 692142342-(4-Bromobenzoyl)-5-methoxybenzoic acid

Procedure

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with 4-bromo-N-methoxy-N-methylbenzamide. It is used in crude form in the following reaction.

Workup

  1. customThis compound is synthesized
  2. customin the following reaction

Sources & evidence

ORD record
ord-53afb685f74248448483626326cbd2ee
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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