Dichloromethane → N-(3-{5-(2-Chloro-4-pyrimidinyl)-2-[4-(methylsulfonyl)-1-piperazinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,5-difluorobenzenesulfonamide

HRID 300631Notes

Reaction equation

HRID 300631 reaction equation
[CH3:1][S:2]([Cl:3])(=[O:4])=[O:5].[Cl:43][CH2:44][Cl:45].[Cl:6][c:7]1[n:8][cH:9][cH:10][c:11](-[c:13]2[c:14](-[c:24]3[c:25]([F:42])[c:26]([NH:30][S:31](=[O:32])(=[O:33])[c:34]4[c:35]([F:41])[cH:36][cH:37][c:38]([F:40])[cH:39]4)[cH:27][cH:28][cH:29]3)[n:15][c:16]([N:18]3[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]3)[s:17]2)[n:12]1>>[CH3:1][S:2](=[O:4])(=[O:5])[N:21]1[CH2:20][CH2:19][N:18]([c:16]2[n:15][c:14](-[c:24]3[c:25]([F:42])[c:26]([NH:30][S:31](=[O:32])(=[O:33])[c:34]4[c:35]([F:41])[cH:36][cH:37][c:38]([F:40])[cH:39]4)[cH:27][cH:28][cH:29]3)[c:13](-[c:11]3[cH:10][cH:9][n:8][c:7]([Cl:6])[n:12]3)[s:17]2)[CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 57989746N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1-piperazinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Product 1

HCID 57989647N-(3-{5-(2-Chloro-4-pyrimidinyl)-2-[4-(methylsulfonyl)-1-piperazinyl]-1,3-thiazol-4-yl}-2-fluorophenyl)-2,5-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-a72ef8b2bd0a4b4da1bab8fe068dd293
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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