HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthalenecarboxaldehyde → (3R)-1-(Naphthalen-2-ylmethyl)-3-tert-butyloxycarbonylaminopyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthalenecarboxaldehyde | HCID 6201 | — |
| Reactant | (3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514397 | — |
| Product | (3R)-1-(Naphthalen-2-ylmethyl)-3-tert-butyloxycarbonylaminopyrrolidine | HCID 69215056 | — |
Reaction Steps
This compound was prepared via the reductive amination method described in 49.2, by reaction of (R)-3-tert-butyloxycarbonylaminopyrrolidine with 2-naphthaldehyde. The residue is purified on a column of silica (eluent: from 100/0 to 90/10 (v/v) dichloromethane/methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423030B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-a313387baa2843c19b9ac2231bc6885f |
| Source note | uspto-grants-2008_09 |