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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30066Generated: October 25, 2026

2-Naphthalenecarboxaldehyde → (3S)-1-(Naphthalen-2-ylmethyl)-3-tert-butyloxycarbonylamino-pyrrolidine

https://huagongshe.com/reaction/30066

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-NaphthalenecarboxaldehydeHCID 6201—
Reactant(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 1514396—
Product(3S)-1-(Naphthalen-2-ylmethyl)-3-tert-butyloxycarbonylamino-pyrrolidineHCID 69213934—

Reaction Steps

This compound was obtained via the reductive amination method described in 49.2, by reaction of (S)-3-tert-butyloxycarbonylaminopyrrolidine with 2-naphthaldehyde. The residue is purified on a column of silica (eluent: from 100/0 to 90/10 (v/v) dichloromethane/methanol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423030B2
Source datasetuspto-grants-2008_09
ORD IDord-dadb7808e29e48798b1fe63f2e673fc1
Source noteuspto-grants-2008_09