3-Ethoxycarbonyl-7,8,9-trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine → (RS)-3-Ethoxycarbonyl-7,9-difluoro-8-{3-[4-(2-hydroxyethoxy)phenyl]-1-piperazinyl}-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine
Reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7](=[O:24])[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]2[n:14]([CH3:16])[cH:15]1)[c:17]([F:23])[c:18]([F:22])[c:19]([F:21])[cH:20]3.[OH:25][CH2:26][CH2:27][O:28][c:29]1[cH:30][cH:31][c:32]([CH:35]2[NH:36][CH2:37][CH2:38][NH:39][CH2:40]2)[cH:33][cH:34]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7](=[O:24])[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]2[n:14]([CH3:16])[cH:15]1)[c:17]([F:23])[c:18]([N:39]1[CH2:38][CH2:37][NH:36][CH:35]([c:32]2[cH:31][cH:30][c:29]([O:28][CH2:27][CH2:26][OH:25])[cH:34][cH:33]2)[CH2:40]1)[c:19]([F:21])[cH:20]3Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-7f7b5932de1349e6a9712d63c4c0c7c8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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