Trifluoroacetic acid → [1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate

Participants

Reaction Steps

A suspension of (1-methanesulfonyl-piperidin-4-yl)-carbamic acid tert-butyl ester (1.14 g, 4.1 mmol, from above) in methylene chloride (15 mL) was treated at room temperature with trifluoroacetic acid (5.3 mL). After stirring for 2 hours, all solvent was removed and the residue was triturated with ether. This was filtered, washed with ether and dried in vacuum to give 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoro-acetic acid (1.20 g, 100% yield). HRMS, observed: 177.0692; Calcd for M+: 177.0698.

Provenance & Evidence