2-(Chloromethyl)-4,6-dimethoxypyrimidine → 1'-[(4,6-dimethoxypyrimidin-2-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

HRID 301030Notes

Reaction equation

HRID 301030 reaction equation
[Cl:44][CH2:45][c:46]1[n:47][c:48]([O:54][CH3:55])[cH:49][c:50]([O:52][CH3:53])[n:51]1.[Cl:56][CH2:57][c:58]1[cH:59][n:60][c:61]([O:62][CH3:63])[n:64][cH:65]1.[NH:1]1[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21.[NH:23]1[c:24]2[c:25]([cH:26][cH:27][cH:28][cH:29]2)[C:30]2([CH2:31][O:32][c:33]3[cH:34][c:35]4[c:36]([cH:37][c:38]32)[CH2:39][CH2:40][O:41]4)[C:42]1=[O:43]>>[N:1]1([CH2:45][c:46]2[n:47][c:48]([O:54][CH3:55])[cH:49][c:50]([O:52][CH3:53])[n:51]2)[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21

Participants

5

Reactant 4

HCID 109652792-(Chloromethyl)-4,6-dimethoxypyrimidineHCID 216981735-(Chloromethyl)-2-methoxypyrimidineHCID 58224164Spiro[furo[2,3-g]-1,4-benzodioxin-8(7H),3'-[3H]indol]-2'(1'H)-one, 2,3-dihydroHCID 592633545,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one

Product 1

HCID 593526121'-[(4,6-dimethoxypyrimidin-2-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-1d522082390b4216aa0d19b67a710834
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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