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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30113Generated: October 25, 2026

Ethyl isocyanate → 4-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethylamide

https://huagongshe.com/reaction/30113

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl isocyanateHCID 8022—
Reactant[2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanoneHCID 58590835—
Product4-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethylamideHCID 11696691—

Reaction Steps

The title compound was prepared from [2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanone (Example 9) and ethyl isocyanate (Aldrich 98%) using the procedure described in Example 12. HRMS, observed: 385.1917, calcd for M+: 385.1914.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423051B2
Source datasetuspto-grants-2008_09
ORD IDord-538797dc37004d4ab5232d6c5d1d9590
Source noteuspto-grants-2008_09