HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1-Boc-piperidine → 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Reactant | (2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-phenyl)-methanone | HCID 58590829 | — |
| Product | 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 58590827 | — |
Reaction Steps
The title compound was prepared from (2-amino-6-chloropyridin-3-yl)-(5-fluoro-2-methoxyphenyl)methanone (Example 19) and 4-amino-1-N-Bocpiperidine (Astatech, >96%) using the procedure described in Step B. Example 6. HRMS, observed: 445.2252, Calcd for (M+H)+: 445.2246.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423051B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-e43b8ffba8e5480d9fd1b26a1d5eb7c5 |
| Source note | uspto-grants-2008_09 |