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HRID30120

反应详情

EQUATION

反应方程式

HRID 30120 的结构方程式

REACTANTS

反应物

2
结构：CS(=O)(=O)N1CCC(N)CC1
HCID11355826

1-(Methanesulfonyl)piperidin-4-amine

C6H14N2O2S

结构：COc1ccc(F)cc1C(=O)c1ccc(Cl)nc1N
HCID58590829

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(F)cc1C(=O)c1ccc(NC2CCN(S(C)(=O)=O)CC2)nc1N
HCID11502705

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (2-amino-6-chloropyridin-3-yl)-(5-fluoro-2-methoxyphenyl)methanone (Example 19) and 1-methanesulfonylpiperidin-4-ylamine (Step A. Example 6) using the procedure described in Step B. Example 6. HRMS, observed: 423.1502, Calcd for (M+H)+: 423.1497. Ki for cdk4=0.040 μM, cdk2=0.098 μM, and IC50 for HCT116 cell line=9 μM.