HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isocyanate → 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | [4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt | HCID 21070627 | — |
| Product | 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethylamide | HCID 11647324 | — |
Reaction Steps
The title compound was prepared from [4-amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and ethyl isocyanate (Aldrich 98%) using the procedure described in Example 24. HRMS, observed: 416.2097, Calcd for (M+H)+: 416.2093.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423051B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-901305e189bf40efb01f2fcd3c7d68ba |
| Source note | uspto-grants-2008_09 |