2-Chloronicotinoyl chloride → 2-Chloro-N-[3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenyl]-nicotinamide

HRID 301311Notes

Reaction equation

HRID 301311 reaction equation
[C:30]([N:31]1[CH2:32][CH2:33][CH:34]([O:35][c:36]2[cH:37][c:38]([C:39]([F:40])([F:41])[F:42])[cH:43][c:44]([NH:45][C:46]([c:47]3[c:48]([Cl:49])[n:50][cH:51][cH:52][cH:53]3)=[O:54])[cH:55]2)[CH2:56][CH2:57]1)([O:58][C:59]([CH3:60])([CH3:61])[CH3:62])=[O:63].[Cl:20][c:21]1[n:22][cH:23][cH:24][cH:25][c:26]1[C:27](=[O:28])[Cl:29].[N:1]1([CH2:6][CH2:7][O:8][c:9]2[cH:10][c:11]([NH2:19])[cH:12][cH:13][c:14]2[C:15]([F:16])([F:17])[F:18])[CH2:2][CH2:3][CH2:4][CH2:5]1>>[N:1]1([CH2:6][CH2:7][O:8][c:9]2[cH:10][c:11]([NH:19][C:27]([c:26]3[c:21]([Cl:20])[n:22][cH:23][cH:24][cH:25]3)=[O:28])[cH:12][cH:13][c:14]2[C:15]([F:16])([F:17])[F:18])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 27745412-Chloronicotinoyl chlorideHCID 219594573-(2-Pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenylamineHCID 219596471-Boc-4-(3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine

Product 1

HCID 219593482-Chloro-N-[3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenyl]-nicotinamide

Sources & evidence

ORD record
ord-5f3ed1f17ec34e039116bb0d910ec45f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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