[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → [2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(4-methoxy-phenyl)-methanone

HRID 30133Notes

Reaction equation

HRID 30133 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.FC(F)(F)C(O)=O.[CH3:26][S:27]([N:30]1[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32][CH2:31]1)(=[O:29])=[O:28]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=[C:4]([NH:36][CH:33]2[CH2:34][CH2:35][N:30]([S:27]([CH3:26])(=[O:29])=[O:28])[CH2:31][CH2:32]2)[N:3]=1

Participants

3

Reactant 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 58590836(2-Amino-6-chloro-pyridin-3-yl)-(4-methoxy-phenyl)-methanone

Product 1

HCID 11689944[2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(4-methoxy-phenyl)-methanone

Procedure

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(4-methoxy-phenyl)-methanone (Example 35) and 1-methanesulfonyl-piperidin-4-ylamine (Step A, Example 6) using the procedure described in Step B. Example 6. HRMS, observed: 405.1595, calcd for (M+H)+: 405.1591.

Sources & evidence

ORD record
ord-223b659e87944b4c94350b36aecf29f5
Source dataset
uspto-grants-2008_09
Patent number
US07423051B2

Reaction notes

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