[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → [2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(4-fluoro-phenyl)-methanone

HRID 30135Notes

Reaction equation

HRID 30135 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.FC(F)(F)C(O)=O.[CH3:25][S:26]([N:29]1[CH2:34][CH2:33][CH:32]([NH2:35])[CH2:31][CH2:30]1)(=[O:28])=[O:27]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=[C:4]([NH:35][CH:32]2[CH2:33][CH2:34][N:29]([S:26]([CH3:25])(=[O:28])=[O:27])[CH2:30][CH2:31]2)[N:3]=1

Participants

3

Reactant 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 58590828(2-Amino-6-chloro-pyridin-3-yl)-(4-fluoro-phenyl)-methanone

Product 1

HCID 11502052[2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(4-fluoro-phenyl)-methanone

Procedure

The title compound was prepared from (2-amino-6-chloro-pyridin-3-yl)-(4-fluorophenyl)methanone (Example 37) and 1-methanesulfonyl-piperidin-4-ylamine (Step A, Example 6) using the procedure described in Step B. Example 6. HRMS, observed: 393.1391, Calcd for (M+H)+: 393.1391.

Sources & evidence

ORD record
ord-98e336a52ddf431da2c9b2f81747194c
Source dataset
uspto-grants-2008_09
Patent number
US07423051B2

Reaction notes

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