1-(4-Aminopiperidin-1-yl)ethan-1-one → 1-{4-[6-Amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-ethanone

Participants

Reaction Steps

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone (Example 43) and 1-(4-amino-piperidin-1-yl)-ethanone (prepared as described in D. Manefti et al, Biorg. Med. Chem. Lett., 13 (2003), 2303-2306) using the procedure described in Step B. Example 6. HRMS, observed: 401.1084, Calcd for (M+H)+: 401.1084.

Provenance & Evidence