4-(3-Fluoro-benzyl)-5-oxo-7-piperazin-1-yl-4,5-dihydro-thieno[3,2-b]pyridine-6-carboxylic acid ethyl ester → 4-(3-Fluoro-benzyl)-7-[4-(5-fluoro-thiophene-2-carbonyl)-piperazin-1-yl]-5-oxo-4,5-dihydro-thieno[3,2-b]pyridine-6-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:2][C:3]([c:4]1[c:5](=[O:6])[n:7]([CH2:8][c:9]2[cH:10][cH:11][cH:12][c:13]([F:14])[cH:15]2)[c:16]2[cH:17][cH:18][s:19][c:20]2[c:21]1[N:22]1[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]1)=[O:28])[CH3:29].[CH:30]([CH3:31])([CH3:32])[O:33][C:34](=[O:35])[c:36]1[c:37]([N:54]2[CH2:55][CH2:56][N:57]([C:60](=[O:61])[c:62]3[s:63][c:64]([F:67])[cH:65][cH:66]3)[CH2:58][CH2:59]2)[c:38]2[c:39]([n:40]([CH2:43][c:44]3[cH:45][c:46]([F:50])[cH:47][cH:48][cH:49]3)[c:41]1=[O:42])[cH:51][cH:52][s:53]2>>[CH2:30]([CH3:31])[O:33][C:34](=[O:35])[c:36]1[c:37]([N:54]2[CH2:55][CH2:56][N:57]([C:60](=[O:61])[c:62]3[s:63][c:64]([F:67])[cH:65][cH:66]3)[CH2:58][CH2:59]2)[c:38]2[c:39]([n:40]([CH2:43][c:44]3[cH:45][c:46]([F:50])[cH:47][cH:48][cH:49]3)[c:41]1=[O:42])[cH:51][cH:52][s:53]2Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-baaaea92e941499f8c5b1248b07e0c09
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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