HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-amino-1-piperidinecarboxylate → 4-[6-Amino-5-(5-fluoro-2-methoxy-4-chloro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-amino-1-piperidinecarboxylate | HCID 100867 | — |
| Reactant | (2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone | HCID 58590823 | — |
| Product | 4-[6-Amino-5-(5-fluoro-2-methoxy-4-chloro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethyl ester | HCID 11554211 | — |
Reaction Steps
The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone (Example 47) and ethyl4-amino-1-piperidine carboxylate (Aldrich 96%) using the procedure described in Step B. Example 6. HRMS, observed: 451.1545, Calcd for (M+H)+: 451.1543.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423051B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-d662b7b1e994447ab29f72792bedc7fd |
| Source note | uspto-grants-2008_09 |