1-(Methanesulfonyl)piperidin-4-amine → [2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(2,6-difluoro-phenyl)-methanone

HRID 30149Notes

Reaction equation

HRID 30149 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:11]=2[F:17])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[CH3:19][S:20]([N:23]1[CH2:28][CH2:27][CH:26]([NH2:29])[CH2:25][CH2:24]1)(=[O:22])=[O:21]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:11]=2[F:17])=[O:9])=[CH:6][CH:5]=[C:4]([NH:29][CH:26]2[CH2:27][CH2:28][N:23]([S:20]([CH3:19])(=[O:22])=[O:21])[CH2:24][CH2:25]2)[N:3]=1

Participants

3

Reactant 2

HCID 113558261-(Methanesulfonyl)piperidin-4-amineHCID 58590833(2-Amino-6-chloro-pyridin-3-yl)-(2,6-difluoro-phenyl)-methanone

Product 1

HCID 11690063[2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(2,6-difluoro-phenyl)-methanone

Procedure

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(2,6-difluoro-phenyl)-methanone (Example 51) and 1-methanesulfonyl-piperidin-4-ylamine (Step A. Example 6) using the procedure described in Step B. Example 6. HRMS, observed: 411.1298, Calcd for (M+H)+: 411.1297.

Sources & evidence

ORD record
ord-ffeb767baf5745509d248a83165dad2f
Source dataset
uspto-grants-2008_09
Patent number
US07423051B2

Reaction notes

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