Ethanol → 1-(1-Fluoro-2-methylpropan-2-yl)piperazine

HRID 301637Notes

Reaction equation

HRID 301637 reaction equation
[C+4:25].[CH2:1]([O:2][C:3](=[O:4])[N:11]1[CH2:12][CH2:13][N:14]([C:17]([CH2:18][F:19])([CH3:20])[CH3:21])[CH2:15][CH2:16]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:22][CH2:23][OH:24].[OH-:26].[OH-:28].[OH-:29].[OH-:30].[OH-:31].[OH-:32].[Pd+2:27]>>[NH:11]1[CH2:12][CH2:13][N:14]([C:17]([CH2:18][F:19])([CH3:20])[CH3:21])[CH2:15][CH2:16]1

Participants

6

Reactant 5

HCID 702EthanolHCID 961Hydroxide6×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 66592460HCID 66592460, compoundHCID 178420935HCID 178420935, compound

Product 1

HCID 575860431-(1-Fluoro-2-methylpropan-2-yl)piperazine

Sources & evidence

ORD record
ord-02a1a373d0e24426b073e05737fdbf1f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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