HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → (RS)-2-Hydrazinocarbonylmethyl-piperidine-1-carboxylic acid tert butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl N-boc-2-piperidineacetate | HCID 11572435 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (RS)-2-Hydrazinocarbonylmethyl-piperidine-1-carboxylic acid tert butyl ester | HCID 59789366 | — |
Reaction Steps
2-Methoxycarbonylmethyl-piperidine-1-carboxylic acid tert butyl ester (8.14 g) in ethanol (150 ml) was treated with hydrazine hydrate (19 ml) and the mixture boiled for 16 h. Solvent was removed at reduced pressure and the residue azeotroped with toluene to give the title compound (8.34 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423052B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-bb1ff17e09f248afaba3fc1e76c7a2e3 |
| Source note | uspto-grants-2008_09 |