Methyl piperidin-2-ylacetate → (1-{1-[5-(4-Fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanoyl}-piperidin-2-yl)-acetic acid methyl ester

HRID 30170Notes

Reaction equation

HRID 30170 reaction equation
[CH3:1][O:2][C:3](=[O:11])[CH2:4][CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][NH:6]1.[CH3:12][C:13]1[S:14][C:15]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)=[C:16]([C:18](O)=[O:19])[N:17]=1>>[CH3:1][O:2][C:3](=[O:11])[CH2:4][CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][N:6]1[C:18]([C:16]1[N:17]=[C:13]([CH3:12])[S:14][C:15]=1[C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=1)=[O:19]

Participants

3

Reactant 2

HCID 5214606Methyl piperidin-2-ylacetateHCID 223241255-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid

Product 1

HCID 66968203(1-{1-[5-(4-Fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanoyl}-piperidin-2-yl)-acetic acid methyl esterYield 60.2%

Procedure

The title compound (2.1 g) was prepared from piperidin-2-yl-acetic acid methyl ester (3.4 g) and 2methyl-5-(4-fluorophenyl)-thiazole-4-carboxylic acid (2.20 g) according to the method of description 20.

Sources & evidence

ORD record
ord-6924f4c94ed74203b94f06a80cb6ba49
Source dataset
uspto-grants-2008_09
Patent number
US07423052B2

Reaction notes

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