反应详情

To a solution of N-Boc-2,5-diphenylpyrrole (1.027 g, 3.22 mmol) in methanol (80 ml) was added palladium (5%) on activated carbon (0.250 g). The reaction mixture was hydrogenated (10 psi) for 1.5 hours. Filtration and evaporation to dryness afforded N-Boc-2,5-diphenylpyrrolidine (1.01 g, 97%). 1H-NMR (CDCl3): δ ppm 7.20-7.60 (m, ArH, 10H), 5.0 (in, ArCH, 2H), 2.45 (m, CH2, 2H), 1.17 (s, CH3, 9H)

1. customfor 1.5 hours
2. filtrationFiltration and evaporation to dryness