HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30247Generated: October 29, 2026
Oxalyl chloride → 1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carbonyl chloride hydrochloride
https://huagongshe.com/reaction/30247
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid trifluoroacetate | HCID 67206234 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carbonyl chloride hydrochloride | HCID 86604300 | — |
Reaction Steps
The product from step c) (2.3 g, 5.18 mmol) in CH2Cl2 (26 ml) was treated with oxalyl chloride (2.3 ml, 26.3 mmol) followed by DMF (4 drops) and the mixture was stirred for 1 hour at 22° C. The solvent was evaporated in vacuo to give the crude subtitle compound as pink solid that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07423056B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-bd6d94572f2c49fda92c40211a4234ed |
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| Source note | uspto-grants-2008_09 |
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