HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 1-Benzyl-4-thiophen-3-yl-piperidine-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-Benzyl-4-thiophen-3-yl-piperidine-3-carboxylic acid | HCID 67207823 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyl-4-thiophen-3-yl-piperidine-3-carbonyl chloride | HCID 86229215 | — |
Reaction Steps
A solution of the product from step d) (4.68 g, 13.8 mmol) in CH2Cl2 (77 ml) was treated with DMF (3-4 drops) and oxalyl chloride (2.72 ml, 31 mmol) at 220C for 1 hour. Next, the solvent was evaporated providing the subtitle compound (4.38 g) that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423056B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-b1718c701a464ab9aeb5b8602ffedecc |
| Source note | uspto-grants-2008_09 |