HCID 131727046, compound → HCID 59789420, compound

HRID 30289Notes

Reaction equation

HRID 30289 reaction equation
C(OC([N:8]1[CH2:20][CH:11]2[C:12]3[CH:13]=[C:14]([Br:19])[S:15][C:16]=3[CH:17]([CH3:18])[CH:10]2[CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[Br:19][C:14]1[S:15][C:16]2[CH:17]([CH3:18])[CH:10]3[CH2:9][NH:8][CH2:20][CH:11]3[C:12]=2[CH:13]=1

Participants

3

Reactant 1

HCID 131727046HCID 131727046, compound

Product 1

HCID 59789420HCID 59789420, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

The product from step b) (50 mg, 0.14 mmol) was dissolved in 2 mL of 4M HCl/dioxane and stirred at room temperature for one hour. The solvent was evaporated leaving a solid that was purified by preparative LC/MS. MS calculated for C10H12BrNS+H: 258, observed: 258 and 260. 1H NMR (CDCl3300 MHz) δ 1.29 (d, 3H), 1.98 (s, 1H), 3.14 (m, 3H), 3.32 (m 2H), 3.50 (m, 1H), 3.70 (m, 1H), 6.74 (s, 1H) ppm.

Workup

  1. customThe solvent was evaporated
  2. customleaving a solid
  3. customthat was purified by preparative LC/MS

Sources & evidence

ORD record
ord-3a83ac56492c42768d2a5ee3b9f734e5
Source dataset
uspto-grants-2008_09
Patent number
US07423056B2

Reaction notes

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