3-Chloromethyl-5-(3,4,5-trimethoxyphenyl)pyridine → 1-(tert-butoxycarbonyl)-4-[N-[4-(methylthio)phenyl]-N-[[3-(3,4,5-trimethoxyphenyl) pyridin-5-yl]methyl]amino]piperidine

HRID 302922Notes

Reaction equation

HRID 302922 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[cH:16][cH:17][c:18]([S:21][CH3:22])[cH:19][cH:20]2)[CH2:12][CH2:13]1.[Cl:23][CH2:24][c:25]1[cH:26][c:27](-[c:31]2[cH:32][c:33]([O:41][CH3:42])[c:34]([O:39][CH3:40])[c:35]([O:37][CH3:38])[cH:36]2)[cH:28][n:29][cH:30]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]([c:15]2[cH:16][cH:17][c:18]([S:21][CH3:22])[cH:19][cH:20]2)[CH2:24][c:25]2[cH:26][c:27](-[c:31]3[cH:32][c:33]([O:41][CH3:42])[c:34]([O:39][CH3:40])[c:35]([O:37][CH3:38])[cH:36]3)[cH:28][n:29][cH:30]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 225578743-Chloromethyl-5-(3,4,5-trimethoxyphenyl)pyridineHCID 225580351-(Tert-butoxycarbonyl)-4-[[4-(methylthio)phenyl]amino]piperidine

Product 1

HCID 225578431-(tert-butoxycarbonyl)-4-[N-[4-(methylthio)phenyl]-N-[[3-(3,4,5-trimethoxyphenyl) pyridin-5-yl]methyl]amino]piperidine

Sources & evidence

ORD record
ord-ff935ce66b7d4a31a315955f7d0bda13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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