HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetone → 2-Amino-4-(5-chloro-2-pyridyl)-3-phenylbutane hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetone | HCID 7678 | — |
| Reactant | 1-(Bromomethyl)-4-chlorobenzene | HCID 69329 | — |
| Reactant | 3-Acetonylpyridine | HCID 238414 | — |
| Reactant | 5-Chloro-2-(chloromethyl)pyridine | HCID 14517151 | — |
| Product | 2-Amino-4-(5-chloro-2-pyridyl)-3-phenylbutane hydrochloride salt | HCID 22270517 | — |
Reaction Steps
5-Chloro-2-choromethylpyridine (Weidmann, K. et al. J. Med. Chem. 1992, 35, 438) and phenylacetone were used in place of 4-chlorobenzyl bromide and 3-pyridylacetone in Step A of Reference Example 4. LC-MS: m/e 261 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07423067B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-05e047b6489b44479102905253a5f15f |
| Source note | uspto-grants-2008_09 |