1-Boc-Azetidine-3-carboxylic acid → 1-(Tert-butoxycarbonyl)-2-ethylazetidine-2-carboxylic acid

HRID 30355Notes

Reaction equation

HRID 30355 reaction equation
[C:1](OC(N1CC(C(O)=O)C1)=O)(C)(C)[CH3:2].[C:15]([O:19][C:20]([N:22]1[CH2:25][CH2:24][CH:23]1[C:26]([OH:28])=[O:27])=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([N:22]1[CH2:25][CH2:24][C:23]1([CH2:1][CH3:2])[C:26]([OH:28])=[O:27])=[O:21])([CH3:18])([CH3:16])[CH3:17]

Participants

3

Reactant 2

HCID 27559811-Boc-Azetidine-3-carboxylic acidHCID 36238861-[(Tert-butoxy)carbonyl]azetidine-2-carboxylic acid

Product 1

HCID 450957281-(Tert-butoxycarbonyl)-2-ethylazetidine-2-carboxylic acid

Procedure

The title compound was prepared following the procedure described for Reference Example 15 substituting 1-tert-butoxycarbonylazetidine-3-carboxylic acid with 1-tert-butoxycarbonylazetidine-2-carboxylic acid at Step A. 1H NMR (500 MHz, CD3OD): δ 3.98-3.90 (m, 1H), 3.80-3.62 (m, 1H), 2.36-1.82 (m, 4H), 1.42 (s, 9H), 1.02 (t, 3H).

Sources & evidence

ORD record
ord-ee4d69775b564da7a71cc7f3e764aaac
Source dataset
uspto-grants-2008_09
Patent number
US07423067B2

Reaction notes

Loading…