6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one → 6-(3,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one

HRID 304262Notes

Reaction equation

HRID 304262 reaction equation
[C:28](=[O:29])([OH:30])[c:31]1[c:32](=[O:49])[n:33]([CH2:45][CH:46]([CH3:47])[CH3:48])[n:34][c:35](-[c:37]2[cH:38][c:39]([F:44])[c:40]([F:43])[cH:41][cH:42]2)[cH:36]1.[F:1][c:2]1[cH:3][cH:4][c:5](-[c:6]2[cH:7][c:8]([CH2:9][N:10]3[CH2:11][CH2:12][N:13]([CH3:14])[CH2:15][CH2:16]3)[c:17](=[O:18])[n:19]([CH2:20][CH:21]([CH3:22])[CH3:23])[n:24]2)[cH:25][c:26]1[CH3:27]>>[CH2:28]([OH:29])[c:31]1[c:32](=[O:49])[n:33]([CH2:45][CH:46]([CH3:47])[CH3:48])[n:34][c:35](-[c:37]2[cH:38][c:39]([F:44])[c:40]([F:43])[cH:41][cH:42]2)[cH:36]1

Participants

3

Reactant 2

HCID 98424496-(4-fluoro-3-methylphenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneHCID 219916384-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219914536-(3,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one

Sources & evidence

ORD record
ord-aa6601a00ef8427eacaf3442c2767645
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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