HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30446Generated: October 29, 2026
Water → [6-(3-Methoxyphenyl)-2-(morpholin-4-ylethyl)pyrimidin-4-yl]-3-pyridylamine
https://huagongshe.com/reaction/30446
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | [2-(Bromoethyl)-6-(3-methoxyphenyl)pyrimidin-4-yl]-3-pyridylamine | HCID 86594232 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | [6-(3-Methoxyphenyl)-2-(morpholin-4-ylethyl)pyrimidin-4-yl]-3-pyridylamine | HCID 59789786 | — |
Reaction Steps
Compound 15 (1 eq) is dissolved in 3 ml of dimethyl acetamide and morpholine (5 eq) is added. The reaction mixture is stirred at 60° C. for 4 h, then cooled down to room temperature. Water is added to the mixture and the crash out is filtered off, washed with water and purified by reverse phase preparatory HPLC, obtaining [6-(3-methoxyphenyl)-2-(morpholin-4-ylethyl)pyrimidin-4-yl]-3-pyridylamine 16.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07423148B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-1b27a57977ce47bf84e62f21ee4e10f9 |
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| Source note | uspto-grants-2008_09 |
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