2-Chloronicotinic acid → (2-Chloro-pyridin-3-yl)-(4-isopropyl-piperazin-1-yl)-methanone

HRID 30467Notes

Reaction equation

[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:11]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)([CH3:13])[CH3:12]>>[Cl:1][C:2]1[C:3]([C:4]([N:17]2[CH2:18][CH2:19][N:14]([CH:11]([CH3:13])[CH3:12])[CH2:15][CH2:16]2)=[O:6])=[CH:7][CH:8]=[CH:9][N:10]=1

Participants

Reactant 2

HCID 762582-Chloronicotinic acid

HCID 780131-Isopropylpiperazine

Product 1

HCID 43421008(2-Chloro-pyridin-3-yl)-(4-isopropyl-piperazin-1-yl)-methanone

Procedure

The title compound was prepared in a manner similar to that described in Step A of Example 9 using 2-chloro-nicotinic acid and 1-isopropyl-piperazine.

Sources & evidence

ORD record: ord-e03235ff8d9646909b1898e03cbaa799
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07423147B2

Reaction notes

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